Welcome to the Open Access System!
OpenAccess@KU is the Academic Open Access System of Kastamonu University. It was established in June 2014 to digitally store and open access the academic outputs of Kastamonu University in international standards. OpenAccess@KU includes academic outputs such as articles, presentations, thesis, books, book chapters, reports produced within the body of Kastamonu University.
Kastamonu Üniversitesi Akademik Arşivi Creative Commons Alıntı-GayriTicari-Türetilemez 4.0 Uluslararası Lisansı ile lisanslanmıştır.
Recent Submissions
Dietary Effect of Withania somnifera Root Powder on Growth, Hematobiochemical Parameters, Immunity, and Disease Resistance to Aeromonas hydrophila in Cyprinus carpio
(2024) Habib, S.S.; Saeed, M.Q.; Masud, S.; Kesbiç, O. S.; Ujan, J.A.; Cravana, C.; Al-Rejaie, S. S; Mohany, M.; Fazio, F.
This study investigates the influence of root powder (WSRP) on different aspects of common carp (), including growth, hematobiochemical parameters, antioxidant status, nonspecific immune response, and resilience to bacterial infections. Over a 60-day period, 180 common carp fingerlings (11.73 ± 0.52 g) were subjected to diets supplemented with increasing WSRP levels (0 (control), 1% (WSRP1), 2.5% (WSRP2.5), and 4% (WSRP4)). Nonspecific immune parameters were evaluated using serum samples collected at intervals of 0, 20, 40, and 60 days. After the feeding trial, the fish underwent experimental challenge with , and relative percentage survival (RPS) was monitored for 14 days. The findings revealed a considerable ( < 0.05) enhancement in growth performance and a decreased feed conversion ratio (FCR) with increasing WSRP supplementation. Additionally, hematological and biochemical profiles exhibited improvements in groups receiving WSRP-enriched diets. Fish serum antioxidant status showed a significant ( < 0.05) increase, as indicated by increased activities of total antioxidant capacity (TAC), superoxide dismutase (SOD), catalase (CAT), and reduced glutathione (GSH) in WSRP4. WSRP-supplemented diets led to remarkable enhancements in lysozyme activity ( = 0.001), phagocytic activity ( = 0.002), and RPS ( = 0.003), peaking in WSRP4 at day 60. Furthermore, WSRP2.5 and WSRP4 demonstrated a substantial decrease ( > 0.05) in serum glucose and cortisol levels compared to other groups. In conclusion, WSRP proves valuable for enhancing growth, blood parameters, antioxidant balance, immune response, and infection resistance in common carp, especially at 2.5%-4% dietary supplementation levels. In the future, it will be crucial to study the long-term effects of WSRP supplementation on fish health, as well as its potential for large-scale aquaculture and economic viability in the aquafeed industry.
Some Approximation Properties of the (p,q)-Stancu-Schurer-Bleimann-Butzer-Hahn Operators
(2024.01.01) Torun, G.
In this article, the p,q-Stancu-Schurer-Bleimann-Butzer-Hahn (p,q-SSBBH) operators are introduced. The Korovkin-type theorem is obtained to show the approximation properties of these operators. Then, the rate of convergence of these operators with the help of the modulus of continuity and Lipschitz-type maximal functions is calculated, respectively. Finally, for the asymptotic behavior of these operators, the Voronovskaja-type theorem is given. Furthermore, the convergence of these operators to the considered function f by plotting the graphs is demonstrated. And, this convergence is compared with the convergence of the p,q-Bleimann-Butzer-Hahn (p,q-BBH) operators to the same function.
Environmental effects of acid mine drainage and rehabilitation options at closed mine site: a case study
(2024.01.01) Konanç, M.U.; Degermenci, G.D.
rregular waste storage at closed mine sites poses severe environmental problems. This study evaluates the concentrations and effects of trace elements released into the environment by mining activity by analyzing soil, water, and sediment samples taken from a copper mining site. According to the data, acidic mine drainage was the main cause of the high concentrations of trace elements in the soil and sediments, including arsenic (As), cadmium (Cd), lead (Pb), and copper (Cu). The concentrations of As, Cd, Pb, and Cu in soil and sediments were 2734-times, 1189-times, 157-times and 32 times higher, respectively, in comparison to the background values of averaged concentrations of these elements in the upper crust. Geological and statistical studies indicate that the primary constituents of these pollutants are chalcopyrite and pyrite derivatives present in the primary rock structure. Using water analysis data from 2011 to 2020, the release of essential trace element into water was investigated to monitor the environmental effects of acidic mine drainage (AMD) from the closed Kuvarshan copper mine in the Artvin region of Turkey. This study demonstrates that trace elements concentrations may change according to local and seasonal factors and highlights the importance of conducting routine environmental monitoring studies.
SIK2: A Novel Negative Feedback Regulator of FGF2 Signaling
(John Wiley and Sons Inc, 2024) Kuser-Abali, G.; Ugurlu-Bayarslan, A.; Yilmaz, Y.; Ozcan, F.; Karaer, F.; Bugra, K.
A wide range of cells respond to fibroblast growth factor 2 (FGF2) by proliferation via activation of the Ras/ERK1/2 pathway. In this study, the potential involvement of salt inducible kinase SIK2) in this cascade within retinal Müller glia is explored. It is found that SIK2 phosphorylation status and activity are modulated in an FGF2-dependent manner, possibly via ERK1/2. With SIK2 downregulation, enhanced ERK1/2 activation with delayed attenuation and increased cell proliferation is observed, while SIK2 overexpression hampers FGF2-dependent ERK1/2 activation. In vitro kinase and site-directed mutagenesis studies indicate that SIK2 targets the pathway element GRB2-associated-binding protein 1 (Gab1) on Ser266. This phosphorylation event weakens Gab1 interactions with its partners growth factor receptor-bound protein 2 (Grb2) and Src homology region 2 domain containing phosphatase 2 (Shp2). Collectively, these results suggest that during FGF2-dependent proliferation process ERK1/2-mediated activation of SIK2 targets Gab1, resulting in downregulation of the Ras/ERK1/2 cascade in a feedback loop.
Multi-dimensional analysis of land use/land cover and urbanization on seasonal variation of land surface temperature in İzmir, Türkiye
(2024.01.01) Isinkaralar, O.; Isinkaralar, K.; Yilmaz, D.; Öztürk, S.
Climate change-induced extreme meteorological phenomena, such as sudden temperature fluctuations, are raising global concerns. Increasing their adaptation capacity against temperature changes between seasons is becoming a more critical issue. The aim of this paper is to explore the association between surface temperature (ST) during the four seasons and urban geography in the city center of Izmir. The study identifies built environment parameters that impact seasonal land surface temperatures (LST) through spatial and statistical analysis at the local scale. At the same time, QUADRANT analysis revealed the spatial distinction between neighborhoods showing high LST compliance on a local scale (cooler summers and warm winters as well as neighborhoods showing LST sensitivity (hotter summers and colder winters. A spatial distinction is also revealed, showing significant differences in vegetation, number of buildings, building heights, and land use/cover change types. Geographic regression simulations show that the density of vegetation is vital in mitigating seasonal LST values, especially in making summers cooler and winters warmer. At the same time, population and built-up area density also play a role in increasing LST. Findings are consistent for neighborhood-scale analyses. Variables explain 26% in autumn, 31% in winter, 34% in spring, and 43% in summer. The study, which reveals the pressure of population and urbanization on temperatures, also highlights the adaptive character of the environment in adjusting the temperatures.