Askin, A.Çelik, H.K.Doganay, Z.2023-10-182023-10-182023.01.012149-7893https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=dspace_ku&SrcAuth=WosAPI&KeyUT=WOS:001069490200004&DestLinkType=FullRecord&DestApp=WOShttps://hdl.handle.net/20.500.12597/17790BACKGROUND/AIMS: In this study, we aimed to compare the effects of propofol and ketofol on hemodynamics, end-tidal carbon dioxide (EtCO2), integrated pulmonary index (IPI), peripheral oxygen saturation (SpO(2)) and sedation quality during endoscopy and colonoscopy performed under anesthesia. MATERIALS AND METHODS: One hundred patients aged 18-79 years with American Society of Anesthesiology class I-III were randomly divided into two groups: the propofol group (1%) and the ketofol mixture group (group P and group K, respectively). Sedation was achieved with 0.15 mL/kg doses of both drugs, followed by additional 0.05 mL/kg doses based on the patients' Ramsey Sedation Scores. Before the procedure, the basal values of heart rate (HR), EtCO2, IPI, and SpO(2) were obtained, as well as instantaneous trend data. systolic blood pressure, diastolic blood pressure, and mean blood pressure values were recorded prior to the procedure (baseline values), at the 1st, 5th, 10th, 15th, 25th, 30th minutes, and at the conclusion of the procedure. The duration of anesthesia and the procedure, the amount of propofol administered, the rate of spontaneous eye opening, and recovery parameters were also recorded. RESULTS: The mean blood pressure values at the 1st, 5th, 10th, 15th, 20th minutes, at the end of the intervention, and at the 5th minute after the procedure were found to be higher in group K compared to group P. HR, SpO(2), EtCO2 and IPI values were higher in group K than in group P. Time to spontaneous eye opening was significantly lower in group K compared to group P. In addition, the recovery period during which the modified Aldrete score was >9 did not differ between groups. Additional doses and total propofol consumed during the procedure were significantly lower in group K than in group P. CONCLUSION: Ketofol appears superior to propofol in endoscopic procedures due to its superior hemodynamic and respiratory stability, without affecting recovery time. Incorporating non-invasive EtCO2 and IPI measurements into standard respiratory monitoring equipment improves monitoring quality and facilitates its execution.eninfo:eu-repo/semantics/openAccessColonoscopyendoscopyketaminepropofolpulmonarysedationArticle10.4274/cjms.2023.2022-45001069490200004264270842536-507X