Palabiyik-Yuceli K, Saziye Sezin, Zeybek, Naciye Dilara, Cinar, Irfan, Akpinar, Erol, Bahador Zırh, Elham, Si Pahi, Hande, Halici, ZekaiPalabiyik-Yuceli̇k S.S., Zeybek N.D., Cinar I., Akpinar E., Bahador Zırh E., Si̇pahi̇ H., Halici Z.Palabiyik-Yucelik, SS, Zeybek, ND, Cinar, I, Akpinar, E, Zirh, EB, Sipahi, H, Halici, Z2023-05-082023-05-082023-03-012023-03-012023.01.011382-6689https://hdl.handle.net/20.500.12597/11753Chronic aluminium(Al) exposure can affect the antioxidant and glutaminergic systems through N-methyl-D-aspartate receptors (NMDAR). This study was aimed to investigate the neurotoxic effect of Al through different mechanisms in rat hippocampus and to evaluate the protective role of epigallocatechin gallate (EGCG), a well-known antioxidant, with simultaneous administration of Al,as well as post-treatment after Al exposure.For this purpose, aluminum chloride(AlCl) was administered simultaneously with two different EGCG doses for 8 weeks as the first part of the study.In the second part of the study, after 4 weeks of AlCl pre-administration, two different EGCG doses were also administered during four additional weeks as post-treatment.Al administration led to oxidative stress and increased acetylcholinesterase levels.NMDAR subunit mRNA expressions were down-regulated by Al, which was apparent in NMDAR1/2B subunits.Simultaneous EGCG treatment has shown a better neuroprotective effect in terms of these mechanisms and represents novel approach for the prevention of neurodegenerative diseases likely to be induced by Al.Chronic aluminium(Al) exposure can affect the antioxidant and glutaminergic systems through N-methyl-D-aspartate receptors (NMDAR). This study was aimed to investigate the neurotoxic effect of Al through different mechanisms in rat hippocampus and to evaluate the protective role of epigallocatechin gallate (EGCG), a well-known antioxidant, with simultaneous administration of Al,as well as post-treatment after Al exposure.For this purpose, aluminum chloride(AlCl3) was administered simultaneously with two different EGCG doses for 8 weeks as the first part of the study.In the second part of the study, after 4 weeks of AlCl3 pre-administration, two different EGCG doses were also administered during four additional weeks as post-treatment.Al administration led to oxidative stress and increased acetylcholinesterase levels.NMDAR subunit mRNA expressions were down-regulated by Al, which was apparent in NMDAR1/2B subunits.Simultaneous EGCG treatment has shown a better neuroprotective effect in terms of these mechanisms and represents novel approach for the prevention of neurodegenerative diseases likely to be induced by Al.falseAluminumEpigallocatechin gallateNMDARNeurotoxicityAluminum | Epigallocatechin gallate | Neurotoxicity | NMDARJournal Article10.1016/j.etap.2023.10406110.1016/j.etap.2023.1040612-s2.0-85145818894WOS:00092058280000136621558981872-7077