Gür M.Şener N.Kaştaş Ç.A.Özkan O.E.Muğlu H.Elmaswari M.A.M.2023-04-122023-04-122017-11-010022152Xhttps://hdl.handle.net/20.500.12597/5462Through a cyclization reaction of 2-phenylbutyric acid with N-phenylthiosemicarbazide and POCl3, novel 1,3,4-thiadiazole derivatives were synthesized. Their structures were confirmed using IR, 1H NMR, and 13C NMR spectroscopies and elemental analysis. The antibacterial activities of the obtained 1,3,4-thiadiazole derivatives were tested against Gram-negative bacteria (Salmonella enteritidis, Salmonella typhimurium, Enterobacter aerogenes, Salmonella infantis, Salmonella kentucky, and Escherichia coli) and Gram-positive bacteria (Staphylococcus aureus, Bacillus subtilis, and Enterococcus durans) using a disk diffusion method. Moreover, an antifungal activity experiment was performed against Candida albicans using the disk diffusion method. It was observed that the synthesized 1,3,4-thiadiazole derivatives exhibited effective antimicrobial activity against S. aureus, E. coli, and C. albicans. Based on these results, the 1,3,4-thiadiazole derivatives can be considered as a source of bioactive agents for pharmacological and medicinal applications.falseArticle10.1002/jhet.29842-s2.0-85034059840