Yumusak, N, Yigin, A, Polat, P F, Hitit, M, Yilmaz, RYumusak N., Yigin A., Polat P., Hitit M., Yilmaz R.Yumusak, N, Yigin, A, Polat, PF, Hitit, M, Yilmaz, R2023-05-092023-05-092018-03-012018-01-012018.01.011505-1773https://hdl.handle.net/20.500.12597/14480The aim of the present study was to investigate the role of ADAMTS-7 gene in the pathogenesis of myocardial dystrophy associated with white muscle disease (WMD) in lambs. A total of 217 cardiac tissue samples from lambs with WMD were used in the study. Histopathological sections of the samples were stained with hematoxylin-eosin (HE) and examined using Western-blot, real-time PCR (RT-PCR) and immunohistochemistry for ADAMTS-7 gene expression, and the findings were statistically evaluated. Histopathological examinations revealed fibrosis associated with hyalinization, necrosis and granular calcifications in cardiomyocytes. Western blot and RT-PCR showed a statistically significant upregulation of ADAMTS-7 (p<0.05) (p<0.05). Immunohistochemical analyses showed that immunopositive cell numbers significantly high for ADAMTS-7 (p<0.05). The study has revealed that ADAMTS-7 gene is significantly expressed in myocardial dystrophy associated with WMD in addition to its role in the pathogenesis of this disease.The aim of the present study was to investigate the role of ADAMTS-7 gene in the pathogenesis of myocardial dystrophy associated with white muscle disease (WMD) in lambs. A total of 217 cardiac tissue samples from lambs with WMD were used in the study. Histopathological sections of the samples were stained with hematoxylin-eosin (HE) and examined using Western-blot, real-time PCR (RT-PCR) and immunohistochemistry for ADAMTS-7 gene expression, and the findings were statistically evaluated. Histopathological examinations revealed fibrosis associated with hyalinization, necrosis and granular calcifications in cardiomyocytes. Western blot and RT-PCR showed a statistically significant upregulation of ADAMTS-7 (p?0.05) (p?0.05). Immunohistochemical analyses showed that immunopositive cell numbers significantly high for ADAMTS-7 (p?0.05). The study has revealed that ADAMTS-7 gene is significantly expressed in myocardial dystrophy associated with WMD in addition to its role in the pathogenesis of this disease.falseADAMTS-7lambmyocardial dystrophywhite muscle diseaseADAMTS-7 | Lamb | Myocardial dystrophy | White muscle diseaseJournal Article10.24425/11902910.24425/1190292-s2.0-85046815720WOS:00043204350001429624002119126212300-2557