Yuzbasioglu M.Kuruuzum-Uz A.Guvenalp Z.Simon A.Tóth G.Sebnem Harput U.Kazaz C.Bilgili B.Duman H.Saracoglu I.Omur Demirezer L.2023-04-122023-04-122015-04-011934578Xhttps://hdl.handle.net/20.500.12597/5783Phytochemical studies of the roots and aerial parts of endemic Arnebia purpurea S. Erik &H. Sumbul resulted in the isolation and characterization of four naphthoquinones [isovalerylalkannin (1), α-methyl-n-butanoyl alkannin (2), acetylalkannin (3), and alkannin (4)], a triterpene derivative [3-O-acetyl-oleanolic acid (5)], a steroid [â-sitosterol (6)], three flavonoid glycosides [isorhamnetin-3-O-rutinoside (7), kaempferol-3-O-rutinoside (8), kaempferol 3-O-(5"-acetyl) apiofuranoside 7-O-rhamnopyranoside (9)] and a phenolic acid [rosmarinic acid (10)]. 3-O-Acetyl-oleanolic acid, isorhamnetin-3-O-rutinoside, kaempferol-3-O-rutinoside, and kaempferol 3-O-(5"-acetyl) apiofuranoside 7-O-rhamnopyranoside are reported from an Arnebia species for the first time. Cytotoxic activities on L929 murine fibrosarcoma cell line of the isolated compounds were investigated using MTT assay. Naphthoquinones (1-4) showed intermediate cytotoxic activity in comparison with the standard, doxorubicin.trueArnebia purpurea | Boraginaceae | Cytotoxicity | Flavonoids | Naphthoquinones | Rosmarinic acid | Steroids | TriterpenesArticle10.1177/1934578x15010004152-s2.0-8493352330025973485