MuĞlu, HalitYakan, HasanBakir, Temel Kan2023-04-072023-04-072020-02-111300-0527https://hdl.handle.net/20.500.12597/3574New bis(isatins-thio/carbohydrazones) based on Schiff bases were prepared from terephthalaldehyde biscarbohydrazone and 5-substituted isatins in the presence of a drop of sulfuric acid under reflux in ethanol. Terephthalaldehyde bis(thio/carbohydrazone) was synthesized by the reaction of (thio)/carbohydrazide and terephthalaldehyde in the presence of a few drops of acetic acid under reflux in ethanol. The structures of these synthesized compounds were determined using IR, H NMR, and C NMR spectroscopy and elemental analysis. The in vitro antioxidant activity of all the compounds was determined by the 1,1-diphenyl-2-picryl hydrazyl (DPPH.) free radical scavenging method. Compound 2 showed the best antioxidant activity.enDPPHIsatinSchiff basescarbohydrazonespectroscopic techniquesJournal Article10.3906/kim-1910-1333488154