Uğraş S., Özçelik O.2023-05-092023-05-092020-01-01https://hdl.handle.net/20.500.12597/15358Objective: Exercise important tool to regulate body energy metabolic system activity by increasing mechanical activity or hormonal effects. In this study, we aimed to examine effects of aerobic exercise on levels of irisin, which increases energy expenditure and nesfatin-1, which suppress energy intake and their connection with CK, which reflects increased muscle injury. Methods: Total of 30 healthy sedentary male preformed 30 min of aerobic running exercise work intensity associated with their anaerobic threshold. Blood samples were taken before and after exercise. Serum irisin nesfatin-1 and creatine kinase (CK) were analysed. Results: During exercise serum irisin and CK levels increased in all subjects (16.4% and 25.7%, respectively). Despite the mean values increased statistically significant, nesfatin-1 levels did not increased in all subjects (12.1%). There was a positive statistically significant correlation between increase of irisin and CK levels. Conclusion: Consequently, exercise induced skeletal muscle activity may cause increase in CK and irisin levels. Nesfatin-1 hormones may not seem to be exercise-induced hormone and did not correlate with increased muscle activity. Moderate intensity aerobic exercise may provide beneficial effects on body energy regulatory systems by altering metabolic hormones.trueAerobic exercise | Creatine kinase | Irisin | Nesfatin-1Article10.5505/TurkHijyen.2020.9132810.5505/TurkHijyen.2020.913282-s2.0-85087292895