Gür M., Şener N., Kaştaş Ç.A., Özkan O.E., Muğlu H., Elmaswari M.A.M.Gur, M, Sener, N, Kastas, CA, Ozkan, OE, Muglu, H, Elmaswari, MAM2023-05-092023-05-092017-11-012017.01.010022-152Xhttps://hdl.handle.net/20.500.12597/12358Through a cyclization reaction of 2-phenylbutyric acid with N-phenylthiosemicarbazide and POCl3, novel 1,3,4-thiadiazole derivatives were synthesized. Their structures were confirmed using IR, 1H NMR, and 13C NMR spectroscopies and elemental analysis. The antibacterial activities of the obtained 1,3,4-thiadiazole derivatives were tested against Gram-negative bacteria (Salmonella enteritidis, Salmonella typhimurium, Enterobacter aerogenes, Salmonella infantis, Salmonella kentucky, and Escherichia coli) and Gram-positive bacteria (Staphylococcus aureus, Bacillus subtilis, and Enterococcus durans) using a disk diffusion method. Moreover, an antifungal activity experiment was performed against Candida albicans using the disk diffusion method. It was observed that the synthesized 1,3,4-thiadiazole derivatives exhibited effective antimicrobial activity against S. aureus, E. coli, and C. albicans. Based on these results, the 1,3,4-thiadiazole derivatives can be considered as a source of bioactive agents for pharmacological and medicinal applications.falseArticle10.1002/jhet.298410.1002/jhet.29842-s2.0-85034059840WOS:00042265400007135783590541943-5193