Ramadan M.A.G., Baloglu M.C., Altunoglu Y.C., Kandemirli F., Burhan H., Aygün A., Sayiner H.S., Ozyigit F., Şen F.Ganim, MA, Baloglu, MC, Altunoglu, YC, Kandemirli, F, Burhan, H, Aygun, A, Sayiner, HS, Ozyigit, F, Sen, F2023-05-092023-05-092020-06-012020.01.012251-7871https://hdl.handle.net/20.500.12597/14301Isatin based materials can exhibit a wide range of biological activities including antimicrobial, antiviral, antifungal, anthelmintic, antitumor, anti-HIV, anti-inflammatory, antidepressant, antioxidant, anticonvulsant, antitubercular, analgesic, and central nervous system depressant activities. In this study, four compounds containing 5-Fluoro-isatin thiosemicarbazone with methoxyphenyl or methoxyphenyl in different positions and zinc complexes were evaluated based on their biological activities. Compound 2 was the strongest compound affecting gramnegative bacteria compared to the other compounds. Also, this compound indicated better antimicrobial activity than positive control antibiotics. Besides, compound 3 was the only compound that inhibited the growth of Salmonella spp. such as Salmonella enteritidis ATCC 13076 and Salmonella typhimurium NRRLE 4463. 5-Fluoro-Isatin thiosemicarbazone and its derivatives also showed DNA protection property from moderate to good protections. Among them, compound 4 displayed the highest DNA binding affinity. These compounds possessed a capacity for utilization as drugs or drug additives based on their effects on bacteria strains and DNA binding affinity.false5-Fluoro-Isatin | Antimicrobial activity | DNA protection | ThiosemicarbazoneArticle10.22052/JNS.2020.03.00710.22052/JNS.2020.03.0072-s2.0-85091853796WOS:000577165100007509517102251-788X