Uğur ERSÖZSıtkıcan OKURMümin Gökhan ŞENOCAKElif DOĞANLatif Emrah YANMAZ2023-04-142023-04-142020-12-01Ersoz, U., Okur, S., Şenocak, M., Doğan, E., Yanmaz, L. (2020). Comparison the Effect of Different Ratios of Ketamine and Propofol (Ketofol) Admixture on Anesthesia Induction in New Zealand White Rabbits. Atatürk Üniversitesi Veteriner Bilimleri Dergisi, 15(3), 251-2561306-6137https://search.trdizin.gov.tr/publication/detail/439872/comparison-the-effect-of-different-ratios-of-ketamine-and-propofol-ketofol-admixture-on-anesthesia-induction-in-new-zealand-white-rabbitshttps://hdl.handle.net/20.500.12597/6991This study was aimed to detect the effects of anesthesia induction with ketamine-propofol (ketofol) admixture in rabbits. Eight, healthy New Zealand white rabbits were randomly received ketofol admixture at the ratio of 1:1, 1:2, and 1:3 with one-week intervals. The length of surgical anesthesia was continuously evaluated until the presence of pedal withdrawal and ear-pinch reflexes. The recovery was assessed by the existence of the righting reflex. The heart rate and respiratory frequency values were recorded at pre-treatment, induction, and two minutes intervals until 20 minutes. There was no statistically significant difference between groups with respect to the ear-pinch reflex and pedal withdrawal reflex. The righting reflex returned earliest at the ratio of 1:1 (8.88 ± 0.63 minutes) which was significantly shorter than the ratio of 1:2 (10.50 ± 0.94 minutes) or 1:3 (13.62 ± 1.93 minutes). The animals receiving ketofol at the ratio of 1:3 had significantly lower respiratory frequency compared to 1:2 and 1:1 ratios at 0, 2, 4, 6, 8, and 12 minutes. The ketofol admixture at the ratio of 1:1 has less respiratory depression effects, and higher doses of propofol in ketofol admixture can be associated with anesthetic complication.enginfo:eu-repo/semantics/openAccessRESEARCH10.17094/ataunivbd.763496439872251256153