Publication: Effect of Tocilizumab on Acinetobacter baumannii Lung Infection in an Immunosuppressed Rat Model
dc.contributor.author | Celebi D., Halici Z., Celebi O., Akgun N., Keskin H., Cinar I., Halici I., Cinisli K.T., Yildirim S. | |
dc.contributor.author | Celebi, D, Halici, Z, Celebi, O, Akgun, N, Keskin, H, Cinar, I, Halici, I, Cinisli, KT, Yildirim, S | |
dc.date.accessioned | 2023-05-09T11:31:42Z | |
dc.date.available | 2023-05-09T11:31:42Z | |
dc.date.issued | 2022-01-01 | |
dc.date.issued | 2022.01.01 | |
dc.description.abstract | Our study aimed to investigate effect of tocilizumab on the lung tissue in the presence of Acinetobacter baumannii infection in immunosuppressed rats. A forty-eight female Wistar albino rats were divided equally into eight groups: Group 1: Healthy (H), Group 2: Immunosuppressed (IM), Group 3: Healthy rats given A. baumannii bacteria (H+BAC), Group 4: Immunosuppressed rats given A. baumannii bacteria (IM+BAC), Group 5: Healthy rats given tocilizumab (H+TCZ), Group 6: Immunosuppressed rats given tocilizumab (IM+TCZ), Group 7: Healthy rats given A. baumannii bacteria and tocilizumab (H+BAC+TCZ), Group 8: Immunosuppressed rats given tocilizumab and A. baumannii bacteria (IM+BAC+TCZ). Fourteen days after the immunosuppression of group 2, 4, 6 and 8 with hydrocortisone, group 3, 4, 7 and 8 were A. baumannii was dropped into the trachea. One hour after A. baumannii application, TCZ was administered to Groups 5, 6, 7 and 8. NF-κB, IL-6 and NLRP3 mRNA expressions were decreased in the IM group compared to the healthy group (P<0.05). Although NF-κB, IL-6 and NLRP3 mRNA expression decreased in the IM+TCZ group compared to the healthy group (P<0.05) NF-κB, IL-6 and NLRP3 mRNA expression increased in the H+TCZ group (P<0.05). Despite decreasing cytokines, A. baumannii has been shown to increase infection-related lung injury. This suggests that in patients currently or recently using steroids, tocilizumab may increase organ damage due to opportunistic infection. | |
dc.identifier.citation | Bozlak, Ö., Cinar, I., Yildirim, S., Cinisli, K., Çelebi̇, D., Halici, I., Halici, Z., Akgun, N., Keski̇n, H. (2022). Effect of Tocilizumab on Acinetobacter baumannii Lung Infection in an Immunosuppressed Rat Model. Kafkas Üniversitesi Veteriner Fakültesi Dergisi, 28(1), 87-96 | |
dc.identifier.doi | 10.9775/kvfd.2021.26491 | |
dc.identifier.eissn | 1309-2251 | |
dc.identifier.endpage | 96 | |
dc.identifier.endpage | 96 | |
dc.identifier.issn | 1300-6045 | |
dc.identifier.scopus | 2-s2.0-85126458790 | |
dc.identifier.startpage | 87 | |
dc.identifier.startpage | 87 | |
dc.identifier.trdizin | 517691 | |
dc.identifier.uri | https://search.trdizin.gov.tr/publication/detail/517691/effect-of-tocilizumab-on-acinetobacter-baumannii-lung-infection-in-an-immunosuppressed-rat-model | |
dc.identifier.volume | 28 | |
dc.identifier.wos | WOS:000735602700001 | |
dc.relation.ispartof | Kafkas Universitesi Veteriner Fakultesi Dergisi | |
dc.relation.ispartof | KAFKAS UNIVERSITESI VETERINER FAKULTESI DERGISI | |
dc.rights | true | |
dc.subject | Acinetobacter baumannii | Immunosuppressed rat | Tocilizumab | |
dc.title | Effect of Tocilizumab on Acinetobacter baumannii Lung Infection in an Immunosuppressed Rat Model | |
dc.title | Effect of Tocilizumab on Acinetobacter baumannii Lung Infection in an Immunosuppressed Rat Model | |
dc.type | Article | |
dspace.entity.type | Publication | |
oaire.citation.issue | 1 | |
oaire.citation.volume | 28 | |
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